3231 is a valid billable ICD-10 diagnosis code for Exudative age-related macular degeneration, bilateral, with active choroidal neovascularization. 3232 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. 11). The 2024 edition of ICD-10-CM H35. 3110, H35. Wet (exudative) AMD, with active choroidal neovascularization H35. 3211 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Scar. It is found in the 2022 version of the ICD-10 Clinical Modification (CM) and can be used in all HIPAA-covered transactions from Oct 01, 2021 - Sep 30, 2022 . injury (trauma) of eye and orbit ( S05. Neovascular glaucoma is an aggressive form of secondary glaucoma. ICD-10-CM Diagnosis Codes that Support Coverage Criteria ICD-10-CM Code Description H35. 1. 3290 - other international versions of ICD-10 H35. H25. Retinal neovascularization, unspecified, left eye. This review aims to provide a comprehensive guide to the pathophysiology, clinical and. CNV is diagnosed by an eye specialist, an ophthalmologist, who. This condition results in damage to the macula, which is part of the retina. the advanced form of non-neovascular AMD, will have one or more zones of well- demarcated retinal pigment epithelial and/or. 2 Even after 10 years, one study found that only 15% of people with no drusen or small drusen at. 8121 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Chronic iridocyclitis. Exudative or neovascular AMD is a more severe subset of AMD which is characterized by the presence of choroidal neovascularization (CNV). 3291 for Exudative age-related macular degeneration, unspecified eye, with active choroidal neovascularization is a medical classification as listed by WHO under the range - Diseases of the eye and. This is the American ICD-10-CM version of H02. Annual Meeting News. Top. ICD-10. A subretinal hemorrhage in the setting of untreated or undertreated choroidal neovascular membranes (CNVMs) can be a devastating consequence leading to irreversible vision loss. Choroidal neovascularization (CNV) is the hallmark of 'wet' or 'exudative' AMD, and is responsible for approximately 90% of cases of severe vision loss due to AMD. It has characteristic findings on optical coherence tomography (OCT) that can be used to distinguish it from other retinal lesions that may appear similar on. 34 Multiple randomized clinical trials have demonstrated that intravitreal injections of anti-VEGF agents to treat choroidal neovascularization in neovascular AMD reduced the risk of moderate vision loss (≥ 15 letters = ≥ 3 lines on a standardized eye chart) to less than 10% over a 24-month period, compared to about 50% in the control group. POHS is asymptomatic until choroidal neovascularization (CNV) or sequelae such as disciform. 32xx) as follows: In the right eye, 1 The left eye, 2 For bilateral, 3Neovascular age-related macular degeneration (AMD) is an advanced form of AMD that can cause rapid and severe vision loss. The 2024 edition of ICD-10-CM D31. 3211: 362. Age-related macular degeneration (AMD) is one of the most common causes of vision loss. H35. Kokame. Neovascularization refers to the growth of new blood vessels. Among eyes with at least 20/40 VA at baseline, 81% maintained 20/40 VA when wet AMD disease activity was detected by ForeseeHome or routine/symptom-based eye examination (Figure 2). Advanced forms of AMD are seen in primarily 2 types, exudative AMD involving the presence of choroidal neovascularization and nonexudative or dry AMD. Neovascular AMD is characterized by choroidal neovascularization (CNV. 819 - other international versions of ICD-10 H43. 61 - other international versions of ICD-10 H35. H35. H35. Neovascular AMD is an advanced form of AMD, characterized by. Age-related macular degeneration (AMD) affects an estimated 14 million people worldwide, and is the leading cause of severe, irreversible vision loss in individuals over the age of 50 years in Western societies. g. 059: Retinal neovascularization, unspecified [associated with age-related macular degeneration] H35. H35. Anti-VEGF injections usually only work for a short time, so most. 25% to 27%. 1, 2, 3 Over 5 million patients worldwide are estimated to have GA, with 1 million in the United States alone. 3120 may differ. 1 About 10% of patients with dry AMD will develop subretinal or choroidal neovascular. The 2024 edition of ICD-10-CM H30. Figure 2. Angiogenesis Inhibitors. The second, usually bilateral, is more commonly confused with wet AMD. 31. 2A9 [convert to ICD-9-CM] Degenerative myopia with choroidal neovascularization, unspecified eye. Although neovascular AMD (nAMD) accounts for only 10% of AMD patients, the majority of severe vision loss associated with AMD is due to nAMD. 3211 became effective on October 1, 2023. Peripapillary choroidal neovascular membranes (PCNM) were first described in 1928 by Lopez and Green. 2A9 may differ. It was first described by Gass in 1966 [ 1] as a serous elevation of the RPE. 3233 became effective on October 1, 2023. 121 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. MNVs contain blood vessels as well as infiltrating immune cells,. The following code(s) above H35. Age-related macular degeneration (AMD) affects one in eight people 60 years of age or older and is the most common cause of irreversible blindness in older persons in developed countries. According to thorough estimates, 200 million people worldwide are estimated to have AMD, and by 2040, this number is projected to rise to close to 300 million. ICD-10-CM Code for Exudative age-related macular degeneration, left eye, with active choroidal neovascularization H35. With PCV, “there’s leaking under the retina, macular edema, intraretinal edema, subretinal hemorrhage, and detachment, so it looks like typical exudative AMD until you do more specific testing,” said Dr. H35. AMD can be dry (nonexudative or atrophic) or wet (exudative or neovascular). 6% with exudative form in at least 1 eye being 1. 351 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Initiation of antiangiogenic treatment halted their growth. Purpose: To describe the clinical and multimodal imaging (MMI) features of age-related macular degeneration (AMD) eyes presenting with intraretinal exudation and no evidence of neovascularization or structural alterations of native retinal vessels. The UK Neovascular AMD Database Report 3: inter-centre variation in VA outcomes and establishing real-world measures of care. We illustrate a case of neMNV using OCTA ( Figure 2). [2] Around 30% of these patients also develop myopic CNVM in the fellow eye as well. Fluorescein angiography (FA) has long been the criterion standard for. This is the American ICD-10-CM version of M31. Neovascular AMD is an advanced form of AMD, characterized by. 3223 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. 1. 059 became effective on October 1, 2023. CLINICAL CLUES. Features of “dry” AMD include hard drusen, soft drusen, retinal pigment epithelial disruption and geographic atrophy. H21. This condition may respond to treatment, while being incurable. It is present in both men and woman of many ethnicities, characterized by serosanguineous detachments of the pigmented epithelium and exudative changes that can commonly lead to subretinal fibrosis. From a clinical perspective, late-stage AMD can be classified atrophic and neovascular AMD. 10) depends on whether the fellow eye in that individual has non-neovascular AMD in the absence of CNV or disciform scarring or whether the eye with drusen or RPE abnormalities, or both, is the fellow eye of a person whose contralateral eye has already. 5. 3210 - other international versions of ICD-10 H35. 29 became effective on October 1, 2023. 89. 5% in patients older than 75. 3120 contain annotation back-references. All neoplasms are classified in this chapter. 30: Unspecified macular degeneration [age-related] H35. 059: Retinal neovascularization, unspecified [associated with age-related macular degeneration] H35. 3220 may differ. 1 About 10% of patients with dry AMD will develop subretinal or choroidal neovascular. 051 became effective on October 1, 2023. A network of abnormal, leaky blood vessels in the choroid is referred to as a choroidal neovascular membrane (CNVM). Showing 1-25: ICD-10-CM Diagnosis Code H44. One subject (10%) had identifiable angioid streaks. 30 may differ. Neovascular or “wet” AMD (nAMD), characterized by macular neovascularization, intra- or subretinal exudation and hemorrhage,. 051 may differ. Macular degenerative changes involve the central part of the retina that is the fovea. H35. In the “wet” type of macular degeneration, abnormal blood vessels (known as choroidal neovascularization or CNV) grow under the retina and macula. AMD is a prevalent condition that constitutes one of the leading causes of irreversible visual impairment in industrialized countries. You may edit the Wiki once you have been on AAPC for 30 days and have made 5 posts. H00-H59. 403 may differ. and neovascularisation. Pathological or degenerative myopia refers to a spherical equivalent of -8. Approximately 10% of patients with nonexudative AMD progress to the exudative form. Wet age-related macular degeneration. H16. 3231. Khanani AM, Skelly A, Bezlyak V, Griner R, Torres LR, Sagkriotis A. Risk factors such as age, race,. Exudative or neovascular AMD is a more severe subset of AMD which is characterized by the presence of choroidal neovascularization (CNV). The Macular Photocoagulation Study (MPS) proved the efficacy of laser photocoagulation in the treatment of CNV secondary. In dry AMD. Early AMD. 051 became effective on October 1, 2023. 30 - other international versions of ICD-10 D31. 22 may differ. Of 51 patients with MNV in the contralateral eye, 23 eyes, 10 eyes, 12 eyes, and 6 eyes showed neovascular AMD, polypoidal choroidal vasculopathy, retinal angiomatous proliferation (RAP), and. The 2024 edition of ICD-10-CM H43. Health and. 3290 is applicable to adult patients aged 15 - 124 years inclusive. eCollection 2021. 1, 2 AMD is a major medical and socioeconomic challenge worldwide and, based on increased life expectancy and a. All neoplasms are classified in this chapter. A few years later, he showed a link between drusen and neovascular AMD. H35. ICD-9-CM 362. 50 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Methods: This was a retrospective review of the MMI and electronic health records for 3 consecutive patients. H35. This is the American ICD-10-CM version of H35. At the initial visit, 19 of the eyes had vision better than 20/200. Patients with neovascular AMD in one eye have a 4 – 12% per year cumulative risk of developing neovascular AMD in the fellow eye. All neoplasms are classified in this chapter. This is the American ICD-10-CM version of H21. Retinal neovascularization, unspecified, unspecified eye. 3233 - other international versions of ICD-10 H35. Age-related macular degeneration (AMD) is the main cause of blindness in the developed world in subjects aged ≥55 years, mainly with risk factors and genetic predisposition, with the number of patients affected being counted in millions and likely to increase with the population longevity. The 2024 edition of ICD-10-CM H35. 051 - H35. nAMD most often starts in one eye, with 18–24% of at-risk, fellow eyes going on to develop the condition within two years [3,3,4,5,6,7,8]. ICD-10 codes covered if selection criteria are met: H35. Geographic Atrophy* / therapy. 351 became effective on October 1, 2023. Wykoff CC, Ou WC, Brown DM, et al. ” The eye will be indicated by the sixth digit in the ICD-10 code, and the stage of AMD will be the seventh digit. When originally published, dry AMD — regardless of which eye — was coded as H35. 1,2,11 The Beaver Dam Eye Study examined the incidence of disease in a cohort of patients aged. These new blood vessels may then bleed and leak fluid, causing the macula to bulge or lift up from. 50 may differ. The retina is a layer of neurosensory tissue in the eye that converts light into neural signals that the brain interprets as images. 89 - other international versions of ICD-10 H25. diagnosis of neovascular AMD (ICD-9-CM code 362. 052 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Peripapillary CNV membranes (PPCNVM) have been associated with multiple etiologies [2, 3]. AMD, and especially nAMD, is the main cause of visual impairment and blindness in developed countries [Citation 2, Citation 5,. Dry age-related macular degeneration (dAMD) is a chronic eye disease that can impair vision and progress to severe central vision loss []. The risk of late AMD, including nAMD and geographic atrophy, increases exponentially in advanced age. Wet or neovascular AMD (nAMD) is characterised by choroidal neovascularization (CNV), resulting in macular haemorrhage, effusion and fibrosis . ICD-9. Neovascular glaucoma is a type of secondary glaucoma where the angle of the eye is closed by “new blood vessels,” hence the name “neovascular. Thirty-two eyes of 32 patients with nAMD were included in this prospective, observational study. H31. Another major application for thermal laser photocoagulation is the treatment of extrafoveal choroidal neovascular membranes that occur in AMD. 3211: 362. The prevalence of non-exudative nAMD is described to be in the range of 6. The following code(s) above H35. 3211 for Exudative age-related macular degeneration, right eye, with active choroidal neovascularization is a medical classification as listed by WHO under. 11948. Neovascular AMD comprises 10% of all cases and can lead to devastating visual loss due to choroidal neovascularization (CNV). The conversion to wet AMD can occur at any stage of dry AMD, but is more likely in. The prevalence of GA goes up with age and it is slightly less than that of neovascular AMD. ” The eye will be indicated by the sixth digit in the ICD-10 code, and the stage of AMD will be the seventh digit. Wet or neovascular AMD (nAMD) is characterised by choroidal neovascularization (CNV), resulting in macular haemorrhage, effusion and fibrosis . 359 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2024 edition of ICD-10-CM C96. This is the American ICD-10-CM version of D22. It was the first time the UC Davis Eye. In patients with neovascular AMD, early detection and prompt treatment improves the visual outcome. 3132 is a valid billable ICD-10 diagnosis code for Nonexudative age-related macular degeneration, bilateral, intermediate dry stage . ICD-10 code H35. Neovascular glaucoma (NVG) is a potentially blinding, intractable and aggressive secondary angle-closure glaucoma that is defined by intraocular neovascularization (NV) of the iris and/or anterior chamber angle with increased intraocular pressure (IOP), which leads to devastating visual consequences that complicate a. 31x4 for advanced atrophic dry. During the past 15 years, new treatment paradigms for neovascular age-related macular degeneration (nvAMD) have evolved due to the advent of intravitreal anti-vascular endothelial growth factor. This is the American ICD-10-CM version of H40. 219 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. ICD-10 code H35. H35. The 2024 edition of ICD-10-CM H35. 3211 for Exudative age-related macular degeneration, right eye, with active choroidal neovascularization is a medical classification as listed by WHO under the range - Diseases of the eye and adnexa . H40-H42. H35. 323 became effective on October 1, 2023. 3 Although an estimated 80% of. Currently, the approved anti-VEGF drugs. This is the American ICD-10-CM version of D31. 1 In the United States, researchers estimate GA’s prevalence is approximately 0. 34 Multiple randomized clinical trials have demonstrated that intravitreal injections of anti-VEGF agents to treat choroidal neovascularization in neovascular AMD reduced the risk of moderate vision loss (≥ 15 letters = ≥ 3 lines on a standardized eye chart) to less than 10% over a 24-month period, compared to about 50% in the control group. It is a common manifestation in both dry and wet types of age-related macular degeneration. 3120 is applicable to adult patients aged 15 - 124 years inclusive. I08. H00-H59 Diseases of the eye and adnexa H35 Other retinal disorders Approximate Synonyms Age related macular degeneration, nonexudative Age-related. 729 Serous Detachment of Retinal Pigment Epithelium, unspecified eye. Q. 3231. Neovascular age-related macular degeneration (exudative or wet AMD) is a prevalent, progressive retinal degenerative macular disease that is characterized by neovascularization of the choroid, mainly affecting the elderly population causing gradual vision impairment. 1-5 In 2010, 2. ICD-10-CM Code for Exudative age-related macular degeneration, right eye, with active choroidal neovascularization H35. 89 - other international versions of ICD-10. 3210 - H35. 212 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Neovascular age-related macular degeneration (exudative or wet AMD) is a prevalent, progressive retinal degenerative macular disease that is characterized by. 3) or a claim for intravitreal injection [Classification Commune des Actes Médicaux (CCAM) procedure code BGLB001] (Figure 1, Step 1). Thus, severe vision loss in many of. 90 became effective on October 1, 2023. 212 may differ. wet AMD, ocular histoplasmosis, angioid streaks A S S E S S M E N T A N D P L A N : Peripapillary choroidal neovascular membrane OD. of the disease, since several therapies exist that reduce vision loss once the advanced neovascular form of AMD occurs. 1 Irreversible central vision loss is highly. Age-related macular degeneration is a potentially progressive maculopathy. The prevalence of. 30 became effective on October 1, 2023. Etiology is unidentifiable in a significant proportion, hence termed as idiopathic. H35. ; Right glaucoma due to vascular disorder; Right mixed mechanism glaucoma; Right neovascular glaucoma. A subset of newly diagnosed patients was identified using a “washout period” (defined as the. The. 31), waist to hip ratio (HR per 0. When using code H35. 4 may differ. 61 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The Epi-Rad90 Ophthalmic System™ (NeoVista, Inc. Nationally Covered Indications. 12. Focal choroidal excavation (FCE) is a newly recognized clinical entity that is often incidentally found, and presents asymptomatic or with mildly decreased visual acuity in the affected eye. H35. This is the American ICD-10-CM version of H35. There is no proven treatment to halt the progression of this degeneration. 2016;30:1462–8. 90 - other international versions of ICD-10 D31. The 2024 edition of ICD-10-CM H35. AMD is classified into two forms, a non-neovascular or “dry” form and a neovascular or “wet” form (Fig. Age-related macular degeneration (AMD) constitutes a prevalent, chronic, and progressive retinal degenerative disease of the macula that affects elderly people and causes central vision impairment as a result of damage to retina, retinal pigment epithelium (RPE), and choriocapillaris [1,2,3]. All 5 of these nonexudative CNV went on to develop exudation in subsequent visits. The 2024 edition of ICD-10-CM H35. EYENET MAGAZINE • 61 Table 2: Wet Age-Related Macular Degeneration (AMD) Right Eye Left Eye Bilateral. 4 became effective on October 1, 2023. Purpose: To describe the clinical and multimodal imaging (MMI) features of age-related macular degeneration (AMD) eyes presenting with intraretinal exudation and no evidence of neovascularization or structural alterations of native retinal vessels. Gass subsequently performed a study on 200 eyes with age-related macular degeneration. The risk of late AMD, including nAMD and geographic atrophy, increases exponentially in advanced age. 31 Nonexudative age-related macular degeneration;. Vascular anomalies of unspecified eye, unspecified eyelid. doi: 10. [1] CNV can also develop in a number of other conditions such as myopic degeneration, chronic. Referred to retina for same day evaluation and aflibercept injections. ICD 10 code for Exudative age-related macular degeneration, unspecified eye, with inactive choroidal neovascularization. However H40. A comparison of the new terms with older terms developed during the fluorescein angiography era is shown in Table 2. Neovascularization in your eye can cause inflammation and scarring and may. Wet AMD. Effective April 1, 2004, OPT with verteporfin continues to be approved for a diagnosis of neovascular AMD with predominately classic subfoveal CNV lesions (where the area of classic CNV occupies ≥ 50% of the area of the entire lesion) at the initial visit as. 3221 H35. Confirmation of neovascular conversion required both a new ICD 9 or 10 diagnosis of neovascular AMD and initiation of anti-VEGF therapy. 1 PCNMs account for 10% of all choroidal neovascular membranes with a female predilection. 351 - other international versions of ICD-10 H35. AMD is more common among White people and is the leading cause of permanent vision loss in older adults. 50 should only be used for claims with a date of service on or before September 30, 2015. ICD 10 code for Exudative age-related macular degeneration, bilateral, with active choroidal. Photocoagulation destroying the invading vascular membrane usually leaves a chorioretinal scar, and a blind spot or scotoma, but. The 2024 edition of ICD-10-CM I08. Search All ICD-10 Toggle Dropdown. Randomized trial of treat-and-extend versus monthly dosing for neovascular age-related macular degeneration: 2-year results of the TREX-AMD study. ICD-10 codes not covered for indications listed in the CPB (not all inclusive): H35. 32x Exudative age-related macular degeneration Reviews, Revisions, and Approvals Date Approval Date Policy adopted from Health Net NMP283 Neovascular (Wet) Macular Degeneration Treatment 11/16 Reviewed – no changes 11/17 11/17Summary. 68. H26. The 2024 edition of ICD-10-CM D31. Wykoff CC, Ou WC, Brown DM, et al. 1 Anti–vascular endothelial growth factor (VEGF) agents such as ranibizumab and aflibercept have revolutionized the treatment of neovascular AMD (nAMD) in Europe since their introduction in 2006 and 2007,. 52 or ICD-10-CM code H35. ICD-10-CM Code. The atrophic regions tend to be multi-focal, may or may not involve the foveal center (Ferris et al. doi: 10. 819 became effective on October 1, 2023. While AMD can arise among middle-aged individuals, studies show that. There are various cytokine pathways involved in the formation and leakage from CNV. “Inflammatory Choroidal Neovascular Membranes: Clinical Profile, Treatment Effectiveness, and Visual Prognosis”. Code Also. Prior treatments have included focal laser therapy, verteporfin (Visudyne. The aim of this study was to describe features of disease activity in patients with treated stable macular neovascularisation (MNV) in neovascular age related macular degeneration (nAMD) using optical coherence tomography angiography (OCTA). H35. What does dry vs. 212 became effective on October 1, 2023. , Fremont, CA) is an epiretinal radiation delivery device developed to treat wet ARMD. J Ophthalmol Vol:2021:9982883. 11). Diagnosis for age-related macular degeneration (ICD-10-CM): H35. Several new codes for proliferative diabetic retinopathy were also added. In the wet, or exudative, form of age-related macular degeneration (AMD or ARMD), pathologic choroidal neovascular membranes (CNVM) develop under the retina. Patients with neovascular AMD in one eye have a 4 – 12% per year cumulative risk of developing neovascular AMD in the fellow eye. In patients with neovascular AMD, early detection and prompt treatment improves the visual outcome. 89 may differ. 1 Severe vision loss from GA is less common than from. 16 should only be used for claims with a date of service on or before September 30, 2015. 5 kg/m 2 1. Severity of AMD was based on the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes. Wet (exudative) AMD, with inactive choroidal. H40. The update effective October 1 adds laterality and also adds “staging. A type 2 excludes note represents "not included here". 3221 became effective on October 1, 2023. 1 Definitions Manual: Skip to content: MDC 02 Diseases and disorders of the eye: Assignment of Diagnosis Codes: Page 6 of 8: A1850 E133521 H04141 H15821 H21322 H35019 H4063X0 H53031: H35019: Changes in retinal vascular appearance, unspecified eye: H35021: Exudative retinopathy, right eye:Cataract with neovascularization, left eye. 311-E10. The prevalence of subclinical non-exudative neovascular AMD in the fellow eyes of patients with unilateral exudative AMD ranged from 6. 3292. Ag e-related macular degeneration (AMD) is the third leading cause of blindness worldwide and the leading cause of legal blindness among people aged 65 years and older in the United States. 1. This allows the doctor to identify where leaking blood vessels in the retina are located. This section shows you chapter-specific coding guidelines to increase your understanding and correct usage of the target ICD-10-CM Volume 1 code. Neovascular age-related macular degeneration (NVAMD) is the sight-threatening late form of AMD leading to extensive structural damage and irreversible functional loss, which is characterized by. 3221 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Annotation Back-References. Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. 3231 for Exudative age-related macular degeneration, bilateral, with active choroidal neovascularization is a medical classification as listed by WHO under the. by 2050. 30 became effective on October 1, 2023. In early AMD, there is usually no vision loss, and there are small or few medium-sized drusen, which are about the thickness of a human hair. Sudden-onset of blurring or distortion of vision is often the presenting symptom in the neovascular form. The following code(s) above H35. [] AMD is the leading cause of irreversible visual loss in the United States, [] with variable degrees of age-related macular changes occurring in 19. 051 - other international versions of ICD-10 H35. Many investigational trials,. 4, 5 Although neovascular AMD (nAMD) can be successfully treated with VEGF inhibitors, the treatment of GA remains a substantially. Correct staging enables more accurate characterization, which is important for understanding risk for visual loss; it also helps to ensure accurate documentation and efficient billing. 3131 - other international versions of ICD-10 H35. -) 124 Other disorders of the eye with mcc or thrombolytic agent. Clinical Features: The distinguishing feature is the presence of choroidal neovascularization (CNV) in the. Choroidal neovascularization (CNV) is the hallmark of 'wet' or 'exudative' AMD, and is responsible for approximately 90% of cases of severe vision loss due to AMD. 359 may differ.